Livin It Up Download Ja Rule

[Ja Rule]Yeah, yeah, yeahWe all myYeahC'mon, c'mon, uhTo all my bitches that be givin' it up, uhTo all my niggas that be livin' it up, we sayTo all my bitches that be givin' it up, ahC'mon

Livin It Up Download Ja Rule

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[Hook: Case & Ja Rule]What, do I do?To all my niggas that be livin' it up, we sayWhat, I doTo all my bitches that be givin' it up, uhhWhat, you doTo all my niggas that be livin' it up, we sayWhat, do I do?To all my bitches that be givin' it up, uhhMy love for youC'mon

[Verse 2: Ja Rule]Bitches, just wanna hold the name exactlyThat's why they suck dick with more passion than applesAnd I ain't mad at'chaNever leave you alone'Cause we fucks when I'm homePhone sex when I'm goneWe both grown, both got minds of our ownBust our freaks off like old dog and Love JonesBeen, in many zones, babyOne hoe, two hoesFuck prizzy bitches, the hoes that do bonoBut you know, the Rule be livin' it upAnd got all these hoes, givin' it upI like a little Rule baby, how cute are you?With a body that rides all sexualI got a stick, I'll ride right next to youDo a doughnut, and cut, and I'll open it upOn the freeway, dick in her mouth, foot on the clutchRule bitch, not givin' a fuck

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window.WaitForIt.wait_for(['nielsen_data_ready', 'sourcepoint_data_ready'], function() var player = bc('bc_player_x2ZHRpZjE6p1jHpT10dASxsVFkkRG2sw'); if (window.gusto.ad_switch.enable_ads_preroll === true) var isPersonalisedAds = gusto.sourcepoint.checkNonIabVendorConsentById( gusto.sourcepoint.nonIabIds.vendors.googleAdManager ), bc_tag_url = ' =/21824617191/capital/video/brightcove_player&description_url=window.location.href&tfcd=0&npa=1&sz=400x300%7C640x480&cmsid=2527446&vid=mediainfo.id&ad_rule=1&gdfp_req=1&output=xml_vast&unviewed_position_start=1&env=vp&impl=s&correlator=random'; // npa means non-personalised ads if (isPersonalisedAds) bc_tag_url = bc_tag_url.replace('npa=1', 'npa=0'); if (window.GLOBALADVERTISING) bc_tag_url += '&cust_params=' + encodeURIComponent('kvplayer=' + 'brightcove') + encodeURIComponent( '&pageid=' + window.GLOBALADVERTISING.pageid ) + encodeURIComponent('&local=' + window.GLOBALADVERTISING.local) + encodeURIComponent( '&adtest=' + window.GLOBALADVERTISING.adtest ) + encodeURIComponent('&section=' + gusto.CATEGORY_PATH) + encodeURIComponent('&at=' + window.GLOBALADVERTISING.at) + encodeURIComponent( '&sensitive=' + window.GLOBALADVERTISING.sensitive ) + encodeURIComponent('&gdpr=' + window.GLOBALADVERTISING.gdpr) + encodeURIComponent( '&gdpr_pd=' + window.GLOBALADVERTISING.gdpr_pd ) + encodeURIComponent( '&gdpr_consent=' + window.GLOBALADVERTISING.gdpr_consent ) + encodeURIComponent('&nmc=' + gusto.nielsen.segments); player.ima3( serverUrl: bc_tag_url, requestMode: "onplay", ); , 10000);

Another mechanism of bladder carcinogenesis is disturbed apoptosis. Apoptosis plays a vital role in morphogenesis, cell turnover and elimination of harmful cells. An inhibition of apoptosis may present a survival advantage on malignant cells harboring genetic alterations and thus promote cancer progression [25]. The main key in apoptosis is the proteolytic activation of the caspases, a class of cysteine aspartyl-specific proteases. Initiator caspases cleave executive caspases which in turn degrade a number of intracellular protein substrates resulting in the characteristic morphological hallmarks of apoptosis. These caspase activities are inhibited by the inhibitors of apoptosis proteins (IAPs) family. Until now, eight human IAPs have been identified, including livin, survivin, c-IAP1, c-IAP2, NAIP, XIAP, ILP-2 and BRUCE [26]. The IAPs let cancer cells resistant to apoptotic stimulation. Members of IAPs have been expressed in many cancers. They are associated with poor prognosis and resistance to radiotherapy and chemotherapy [27].

Livin was recently identified to be a novel anti-apoptotic gene. Livin contains a single copy of a baculovirus IAP repeat (BIR) as well as a ring-type zinc finger domain. The livin gene is located on chromosome 20 at band q13. This gene has two transcript variants (isoform α and isoform β), which have variable antiapoptotic properties [28].

Representative immunohistochemical staining of livin in human bladder cancer. (A) Livin showed negative expression in non neoplastic bladder tissue. (B) Low expression in low grade TCC. (C) High expression in high grade TCC. (D) Low expression in SCC grade I. (E) High expression in SCC grade II ( 400; counterstained with hematoxylin).

TCC cases showed lower SOX2 expression (45/82, 54.9%) than SCC cases (23/35, 65.7%) (P = 0.189). Similarly, TCC cases showed positivity for livin in 51/82 (62.2%) cases which was lower than that detected in SCC cases, 24/35 (68.6%) of cases (P = 0.330).

An analysis of overall-free survival in patients with bladder cancer by the Kaplan-Meier method. (A) According to SOX2 low/high expression in TCC patients (P

We observed that SOX2 and livin expressions were significantly higher in tumor tissues compared with their adjacent non-neoplastic tissues. SOX2 high expression was more in SCC cases (65.7%) than in TCC cases (54.9%). Furthermore, SCC cases showed higher positivity for livin than that detected in TCC cases (68.6% and 62.2%, respectively). However, such differences were not statistically significant (P = 0.189 and P = 0.330, respectively).

These results were consistent with previous studies in which SOX2 was over-expressed in esophageal, colorectal, breast and lung carcinomas [16, 17, 21, 22]. However, in gastric cancer, SOX2 was downregulated [38]. Also reports issued by Dai et al [30] and Gazzaniga et al [31] stated that livin was over-expressed in lung and bladder cancers, respectively.

To the best of our knowledge, this study is the first to evaluate the expression of both SOX2 and livin in primary bladder carcinomas including TCC and SCC regarding bilharziasis status. We found no significant line of demarcation between bilharziasis associated and non-bilharziasis associated bladder carcinomas regarding their SOX2 and livin expressions suggesting that bilharziasis may have no significant role in up-regulation of either SOX2 or livin in TCC and SCC.

Also we are the first to rule out the expression of SOX2 in bladder SCC. We found that SOX2 expression was significantly correlated with tumor grade of both TCC and SCC (P = 0.007 and 0.014, respectively). In previous reports, SOX2 high expression was detected in high-grade more than in low-grade TCC [39]. It has been accepted that SOX2 expression was significantly associated with higher histological grade of esophageal carcinoma [16]. Accordingly, the results on the role of SOX2 in bladder cancer were coincided with that in other cancers.

To the best of our knowledge, this study is the first to analyze the expression of livin in bladder SCC. Our findings showed significant correlation between livin expression and tumor grade of both TCC and SCC (P = 0.031 and P = 0.005, respectively). This is in accordance with the results of Wang et al [27] who found a direct correlation between livin expression and higher-grade tumors. However, Gazzaniga et al [31] and Zhu et al [42] revealed a differential expression pattern of livin in bladder tissues.

In our study, livin expression was proved to be higher in MIBC (pT2-pT3) than that in non-MIBC (pTa-pT1) but results did not reach a significant level. Similarly, Zhu et al [42] found no significant difference in livin expression between non-muscle infiltrating TCC and muscle infiltrating TCC.

Concerning the survival analysis, we found that high expression of livin in both TCC and SCC was significantly correlated with poor OS (P = 0.025 and P = 0.21, respectively). According to these results, we emphasize that high livin expression acts as a powerful prognostic factor in bladder cancer progression.

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